Mechanical ventilation triggers hippocampal apoptosis by vagal and dopaminergic pathways.

  title={Mechanical ventilation triggers hippocampal apoptosis by vagal and dopaminergic pathways.},
  author={Adri{\'a}n Gonz{\'a}lez-L{\'o}pez and In{\'e}s L{\'o}pez-Alonso and Alina Aguirre and Laura Amado-Rodr{\'i}guez and Estefan{\'i}a Batalla-Sol{\'i}s and Aurora Astudillo and Cristina Tom{\'a}s-Zapico and Antonio Fueyo and Claudia C dos dos Santos and Konrad Talbot and Guillermo M. Albaiceta},
  journal={American journal of respiratory and critical care medicine},
  volume={188 6},
RATIONALE Critically ill patients frequently develop neuropsychological disturbances including acute delirium or memory impairment. The need for mechanical ventilation is a risk factor for these adverse events, but a mechanism that links lung stretch and brain injury has not been identified. OBJECTIVES To identify the mechanisms that lead to brain dysfunction during mechanical ventilation. METHODS Brains from mechanically ventilated mice were harvested, and signals of apoptosis and… CONTINUE READING
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