Mechanical ventilation guided by esophageal pressure in acute lung injury.

  title={Mechanical ventilation guided by esophageal pressure in acute lung injury.},
  author={Daniel S. Talmor and Todd W Sarge and Atul Malhotra and Carl R O'donnell and Ray Ritz and Alan Lisbon and Victor Novack and Stephen H Loring},
  journal={The New England journal of medicine},
  volume={359 20},
BACKGROUND Survival of patients with acute lung injury or the acute respiratory distress syndrome (ARDS) has been improved by ventilation with small tidal volumes and the use of positive end-expiratory pressure (PEEP); however, the optimal level of PEEP has been difficult to determine. In this pilot study, we estimated transpulmonary pressure with the use of esophageal balloon catheters. We reasoned that the use of pleural-pressure measurements, despite the technical limitations to the accuracy… CONTINUE READING
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