Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin

@inproceedings{MllerRedetzky2014MechanicalVD,
  title={Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin},
  author={Holger Christian M{\"u}ller-Redetzky and Daniel V Will and Katharina Hellwig and Wolfgang Kummer and Thomas Tschernig and Uwe Pfeil and Renate Paddenberg and Michael Dieter Menger and Olivia Kershaw and Achim D Gruber and Norbert Weissmann and Stefan Hippenstiel and Norbert Suttorp and Martin Witzenrath},
  booktitle={Critical care},
  year={2014}
}
INTRODUCTION Ventilator-induced lung injury (VILI) contributes to morbidity and mortality in acute respiratory distress syndrome (ARDS). Particularly pre-injured lungs are susceptible to VILI despite protective ventilation. In a previous study, the endogenous peptide adrenomedullin (AM) protected murine lungs from VILI. We hypothesized that mechanical ventilation (MV) contributes to lung injury and sepsis in pneumonia, and that AM may reduce lung injury and multiple organ failure in ventilated… CONTINUE READING