Mechanical unloading versus neurohumoral stimulation on myocardial structure and endocrine function In vivo.

@article{Lisy2000MechanicalUV,
  title={Mechanical unloading versus neurohumoral stimulation on myocardial structure and endocrine function In vivo.},
  author={Ondrej Lisy and Margaret M. Redfield and Sofija Jovanovi{\'c} and Michihisa Jougasaki and Aleksandar Jovanovi{\'c} and Hanna Leskinen and Andre Terzic and John C. Burnett},
  journal={Circulation},
  year={2000},
  volume={102 3},
  pages={338-43}
}
BACKGROUND-Mechanical load and humoral stimuli such as endothelin (ET) and angiotensin II (Ang II) are potent modulators of cardiac structure and endocrine function, specifically gene expression and production and release of atrial natriuretic peptide (ANP). We define the contribution of mechanical load compared with neurohumoral stimulation in vivo with specific focus on myocardial and circulating ANP during chronic myocardial unloading produced by thoracic inferior vena caval constriction… CONTINUE READING

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