Mechanical unloading restores beta-adrenergic responsiveness and reverses receptor downregulation in the failing human heart.

@article{OgletreeHughes2001MechanicalUR,
  title={Mechanical unloading restores beta-adrenergic responsiveness and reverses receptor downregulation in the failing human heart.},
  author={Monique L. Ogletree-Hughes and Linda B. Stull and Wendy E. Sweet and Nicholas Gerard Smedira and P Mccarthy and Christine Schomisch Moravec},
  journal={Circulation},
  year={2001},
  volume={104 8},
  pages={881-6}
}
BACKGROUND Mechanical unloading of the failing human heart with a left ventricular assist device (LVAD) results in clinically documented reversal of chamber dilation and improvement of cardiac function. We tested the hypothesis that LVAD support normalizes the ability of cardiac muscle to respond to sympathetic nervous system stimulation by reversing the downregulation of beta-adrenergic receptors. METHODS AND RESULTS Human LV tissue was obtained from nonfailing hearts of unmatched organ… CONTINUE READING

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