Mechanical unloading of the failing human heart fails to activate the protein kinase B/Akt/glycogen synthase kinase-3beta survival pathway.

Abstract

BACKGROUND Left ventricular assist device (LVAD) support of the failing human heart improves myocyte function and increases cell survival. One potential mechanism underlying this phenomenon is activation of the protein kinase B (PKB)/Akt/glycogen synthase kinase-3beta (GSK-3beta) survival pathway. METHODS AND RESULTS Left ventricular tissue was obtained… (More)

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Cite this paper

@article{Razeghi2003MechanicalUO, title={Mechanical unloading of the failing human heart fails to activate the protein kinase B/Akt/glycogen synthase kinase-3beta survival pathway.}, author={Peter Razeghi and Brian A. Bruckner and Saumya G Sharma and Keith A. Youker and O. H. Frazier and Heinrich Taegtmeyer}, journal={Cardiology}, year={2003}, volume={100 1}, pages={17-22} }