Mechanical unfolding of the beet western yellow virus -1 frameshift signal.

  title={Mechanical unfolding of the beet western yellow virus -1 frameshift signal.},
  author={Katherine H White and Marek Orzechowski and Dominique Fourmy and Koen Visscher},
  journal={Journal of the American Chemical Society},
  volume={133 25},
Using mechanical unfolding by optical tweezers (OT) and steered molecular dynamics (SMD) simulations, we have demonstrated the critical role of Mg(2+) ions for the resistance of the Beet Western Yellow Virus (BWYV) pseudoknot (PK) to unfolding. The two techniques were found to be complementary, providing information at different levels of molecular scale. Findings from the OT experiments indicated a critical role of stem 1 for unfolding of the PK, which was confirmed in the SMD simulations. The… CONTINUE READING
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