Mechanical testing of mouse carotid arteries: from newborn to adult.

  title={Mechanical testing of mouse carotid arteries: from newborn to adult.},
  author={Mazyar Amin and Victoria Le and Jessica E. Wagenseil},
  journal={Journal of visualized experiments : JoVE},
The large conducting arteries in vertebrates are composed of a specialized extracellular matrix designed to provide pulse dampening and reduce the work performed by the heart. The mix of matrix proteins determines the passive mechanical properties of the arterial wall(1). When the matrix proteins are altered in development, aging, disease or injury, the arterial wall remodels, changing the mechanical properties and leading to subsequent cardiac adaptation(2). In normal development, the… CONTINUE READING


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