Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis.

@article{Sato1999MechanicalTI,
  title={Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis.},
  author={Masahiro Sato and Takahiro Ochi and Takanobu Nakase and Seiichi Hirota and Yukihiko Kitamura and Shintaro Nomura and Natsuo Yasui},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1999},
  volume={14 7},
  pages={1084-95}
}
Bone lengthening with osteotomy and gradual distraction was achieved in 57 rats, and the effect of mechanical tension-stress on gene expression of bone morphogenetic proteins (BMPs) was investigated by in situ hybridization and Northern blot analysis using probes of BMP-2, BMP-4, BMP-6, BMP-7, and growth/differentiation factor (GDF)-5. There was a lag phase for 7 days after femoral osteotomy until gradual distraction was carried out for 21 days at a rate of 0. 25 mm/12 h using a small external… CONTINUE READING

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Bone morphogenetic pro- teins. In: Bilezikian JP, Raisz LG, Rodan GA (eds.) Principles of Bone Biology

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