Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functions.

  title={Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functions.},
  author={Beate Eckes and Manon C. Zweers and Zhigang Zhang and Ralf Hallinger and Cornelia Mauch and Monique Aumailley and Thomas Krieg},
  journal={The journal of investigative dermatology. Symposium proceedings},
  volume={11 1},
The extracellular matrix (ECM) environment in connective tissues provides fibroblasts with a structural scaffold and modulates cell shape, but it also profoundly influences the fibroblast phenotype. Here we studied fibroblasts cultured in a three-dimensional network of native collagen, which was either mechanically stressed or relaxed. Mechanical load induces fibroblasts that synthesize abundant ECM and a characteristic array of cytokines/chemokines. This phenotype is reminiscent of late… CONTINUE READING
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