Mechanical stretching stimulates collagen synthesis via down-regulating SO2/AAT1 pathway

@inproceedings{Liu2016MechanicalSS,
  title={Mechanical stretching stimulates collagen synthesis via down-regulating SO2/AAT1 pathway},
  author={Jia Liu and Wen Yu and Yan Qing Liu and Selena Ying Chen and Yaqian Huang and Xiaohui Li and Cuiping Liu and Yanqiu Zhang and Zhenzhen Li and Jie Du and Chaoshu Tang and Junbao Du and Hongfang Jin},
  booktitle={Scientific reports},
  year={2016}
}
The aim of the study was to investigate the role of endogenous sulfur dioxide (SO2)/ aspartate aminotransferase 1 (AAT1) pathway in stretch-induced excessive collagen expression and its mechanism. The mechanical stretch downregulated SO2/AAT1 pathway and increased collagen I and III protein expression. Importantly, AAT1 overexpression blocked the increase… CONTINUE READING