Mechanical stretch up-regulates the B-type natriuretic peptide system in human cardiac fibroblasts: a possible defense against transforming growth factor-β mediated fibrosis

@inproceedings{Watson2012MechanicalSU,
  title={Mechanical stretch up-regulates the B-type natriuretic peptide system in human cardiac fibroblasts: a possible defense against transforming growth factor-β mediated fibrosis},
  author={Christopher J E Watson and Dermot M Phelan and Maojia Xu and Patrick Collier and Rois{\'i}n Neary and Albert Smolenski and Mark Thomas Ledwidge and K. McDonald and John A. Baugh},
  booktitle={Fibrogenesis & tissue repair},
  year={2012}
}
BACKGROUND Mechanical overload of the heart is associated with excessive deposition of extracellular matrix proteins and the development of cardiac fibrosis. This can result in reduced ventricular compliance, diastolic dysfunction, and heart failure. Extracellular matrix synthesis is regulated primarily by cardiac fibroblasts, more specifically, the active myofibroblast. The influence of mechanical stretch on human cardiac fibroblasts' response to pro-fibrotic stimuli, such as transforming… CONTINUE READING
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