Mechanical stretch stimulates growth of vascular smooth muscle cells via epidermal growth factor receptor.

  • H Iwasaki, S Eguchi, +2 authors Y Hirata
  • Published 2000 in
    American journal of physiology. Heart and…
We have studied whether activation of epidermal growth factor receptor (EGFR) is involved in stretch-induced extracellular signal-regulated kinase 1/2 (ERK1/2) activation and protein synthesis in cultured rat vascular smooth muscle cells (VSMC). Cyclic stretch (1 Hz) induced a rapid (within 5 min) phosphorylation of ERK1/2, an effect that was time and… (More)