Mechanical stretch activates type 2 cyclooxygenase via activator protein-1 transcription factor in human myometrial cells.

@article{Sooranna2004MechanicalSA,
  title={Mechanical stretch activates type 2 cyclooxygenase via activator protein-1 transcription factor in human myometrial cells.},
  author={Suren R Sooranna and Yooni Lee and Louise U. Kim and Aarthi R. Mohan and Phillip R. Bennett and Mark R. D. Johnson},
  journal={Molecular human reproduction},
  year={2004},
  volume={10 2},
  pages={109-13}
}
The uterus is subject to stretch throughout pregnancy, which, in the presence of progesterone, is a potent stimulus for uterine growth. However, in the absence of progesterone or when stretch is excessive, as in multiple pregnancy, it may provoke the onset of labour. We have investigated the effect of stretch on prostaglandin synthesis in primary human uterine myocytes [non-pregnant (NP), pregnant not in labour (NL) and pregnant in labour (L)]. The cells were grown on flexible bottom culture… CONTINUE READING