Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes.

  title={Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes.},
  author={J Pan and Keiichi Fukuda and Masaki Saito and Jyunko Matsuzaki and Hiroaki Kodama and Motoaki Sano and Tomosaburo Takahashi and Takahiro A Kato and Satoshi Ogawa},
  journal={Circulation research},
  volume={84 10},
This study was designed to determine whether mechanical stretch activates the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway in cardiomyocytes and, if so, by what mechanism. Neonatal rat/murine cardiomyocytes were cultured on malleable silicone dishes and were stretched by 20%. Mechanical stretch induced rapid phosphorylation of JAK1, JAK2, Tyk2, STAT1, STAT3, and glycoprotein 130 as early as 2 minutes and peaked at 5 to 15 minutes. It also caused gel… CONTINUE READING


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