Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II

Abstract

The angiotensin II type 1 (AT1) receptor has a crucial role in load-induced cardiac hypertrophy. Here we show that the AT1 receptor can be activated by mechanical stress through an angiotensin-II-independent mechanism. Without the involvement of angiotensin II, mechanical stress not only activates extracellular-signal-regulated kinases and increases… (More)
DOI: 10.1038/ncb1137

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Cite this paper

@article{Zou2004MechanicalSA, title={Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II}, author={Yun-zeng Zou and Hiroshi Akazawa and Yingjie Qin and Masanori Sano and Hiroyuki Takano and Tohru Minamino and Noriko Makita and Koji Iwanaga and Weidong Zhu and Sumiyo Kudoh and Haruhiro Toko and Koichi Tamura and Minoru Kihara and Toshio Nagai and Akiyoshi Fukamizu and Satoshi Umemura and Taroh Iiri and Toshiro Fujita and Issei Komuro}, journal={Nature Cell Biology}, year={2004}, volume={6}, pages={499-506} }