Mechanical strain induces involution-associated events in mammary epithelial cells

  title={Mechanical strain induces involution-associated events in mammary epithelial cells},
  author={Ana Quaglino and Marcelo J. Salierno and Jesica V. Pellegrotti and Natalia Rubinstein and Edith Claudia Kordon},
  journal={BMC Cell Biology},
  pages={55 - 55}
Shortly after weaning, a complex multi-step process that leads to massive epithelial apoptosis is triggered by tissue local factors in the mouse mammary gland. Several reports have demonstrated the relevance of mechanical stress to induce adaptive responses in different cell types. Interestingly, these signaling pathways also participate in mammary gland involution. Then, it has been suggested that cell stretching caused by milk accumulation after weaning might be the first stimulus that… CONTINUE READING
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Involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ

  • CJ Watson
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