Mechanical strain increases expression of the brain natriuretic peptide gene in rat cardiac myocytes.

@article{Liang1997MechanicalSI,
  title={Mechanical strain increases expression of the brain natriuretic peptide gene in rat cardiac myocytes.},
  author={Faquan Liang and Jing Wu and Mikl{\'o}s Garami and David G. Gardner},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 44},
  pages={
          28050-6
        }
}
Using a device that applies cyclical strain (1 Hz) to ventricular cardiocytes cultured on collagen-coated silicone elastomer surfaces, we have demonstrated strain-dependent increases in brain natriuretic peptide (BNP) secretion, BNP mRNA levels, and expression of a transiently transfected -1595 human BNP-luciferase reporter. When actinomycin D (10 microM) was introduced concomitantly with the strain stimulus, the strain-induced increase in BNP mRNA was eliminated, and the decay of transcripts… CONTINUE READING

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