Mechanical strain and estrogen activate estrogen receptor alpha in bone cells.

@article{Jessop2001MechanicalSA,
  title={Mechanical strain and estrogen activate estrogen receptor alpha in bone cells.},
  author={Helen L Jessop and Maria Sj{\"o}berg and Ming Zhao Cheng and Gul Zaman and Caroline P. D. Wheeler-Jones and Lance Edward Lanyon},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2001},
  volume={16 6},
  pages={1045-55}
}
Bone cells' early responses to estrogen and mechanical strain were investigated in the ROS 17/2.8 cell line. Immunoblotting with antiphosphorylated estrogen receptor a (ER-alpha) antibody showed that when these cells were exposed for 10 minutes to estrogen (10(-8) M) or a single period of cyclic dynamic strain (peak 3400 microepsilon, 1 Hz, 600 cycles), there was an increase in the intensity of a 66-kDa band, indicating phosphorylation of ser122 in the amino terminus of ER-alpha. Increased… CONTINUE READING

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