Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells.

@article{Zhang2009MechanicalSA,
  title={Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells.},
  author={Yan-Liang Zhang and John A. Frangos and Mirianas Chachisvilis},
  journal={American journal of physiology. Cell physiology},
  year={2009},
  volume={296 6},
  pages={C1391-9}
}
The molecular mechanisms by which bone cells transduce mechanical stimuli into intracellular biochemical responses have yet to be established. There is evidence that mechanical stimulation acts synergistically with parathyroid hormone PTH(1-34) in mediating bone growth. Using picosecond time-resolved fluorescence microscopy and G protein-coupled receptor conformation-sensitive fluorescence resonance energy transfer (FRET), we investigated conformational transitions in parathyroid hormone type 1… CONTINUE READING