Mechanical stimulation induces formin-dependent assembly of a perinuclear actin rim.

  title={Mechanical stimulation induces formin-dependent assembly of a perinuclear actin rim.},
  author={Xiaowei Shao and Qingsen Li and Alex Mogilner and Alexander D Bershadsky and G. V. Shivashankar},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 20},
Cells constantly sense and respond to mechanical signals by reorganizing their actin cytoskeleton. Although a number of studies have explored the effects of mechanical stimuli on actin dynamics, the immediate response of actin after force application has not been studied. We designed a method to monitor the spatiotemporal reorganization of actin after cell stimulation by local force application. We found that force could induce transient actin accumulation in the perinuclear region within ∼ 2… CONTINUE READING
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