Mechanical signals and mechanosensitive modulation of intracellular [Ca(2+)] in smooth muscle.

  • S S An, Chunxu Hai
  • Published 2000 in American journal of physiology. Cell physiology


We tested the hypothesis that strain is the primary mechanical signal in the mechanosensitive modulation of intracellular Ca(2+) concentration ([Ca(2+)](i)) in airway smooth muscle. We found that [Ca(2+)](i) was significantly correlated with muscle length during isotonic shortening against 20% isometric force (F(iso)). When the isotonic load was changed to… (More)


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