Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology.

@article{Ingber2002MechanicalSA,
  title={Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology.},
  author={Donald E. Ingber},
  journal={Circulation research},
  year={2002},
  volume={91 10},
  pages={877-87}
}
Great advances have been made in the identification of the soluble angiogenic factors, insoluble extracellular matrix (ECM) molecules, and receptor signaling pathways that mediate control of angiogenesis--the growth of blood capillaries. This review focuses on work that explores how endothelial cells integrate these chemical signals with mechanical cues from their local tissue microenvironment so as to produce functional capillary networks that exhibit specialized form as well as function… CONTINUE READING
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