Mechanical regulation of chondrogenesis

@inproceedings{OConor2013MechanicalRO,
  title={Mechanical regulation of chondrogenesis},
  author={Christopher J. O’Conor and Natasha D Case and Farshid Guilak},
  booktitle={Stem Cell Research & Therapy},
  year={2013}
}
Mechanical factors play a crucial role in the development of articular cartilage in vivo. In this regard, tissue engineers have sought to leverage native mechanotransduction pathways to enhance in vitro stem cell-based cartilage repair strategies. However, a thorough understanding of how individual mechanical factors influence stem cell fate is needed to predictably and effectively utilize this strategy of mechanically-induced chondrogenesis. This article summarizes some of the latest findings… CONTINUE READING
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Levenston ME: Ion-channel regulation of chondrocyte matrix synthesis in 3D culture under static and dynamic compression

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