Mechanical regulation of cardiac fibroblast profibrotic phenotypes

  title={Mechanical regulation of cardiac fibroblast profibrotic phenotypes},
  author={Kate M\oller Herum and Jonas Choppe and Aditya Kumar and Adam J Engler and Andrew D. McCulloch},
  booktitle={Molecular biology of the cell},
Cardiac fibrosis is a serious condition currently lacking effective treatments. It occurs as a result of cardiac fibroblast (CFB) activation and differentiation into myofibroblasts, characterized by proliferation, extracellular matrix (ECM) production and stiffening, and contraction due to the expression of smooth muscle α-actin. The mechanical properties of myocardium change regionally and over time after myocardial infarction (MI). Although mechanical cues are known to activate CFBs, it is… CONTINUE READING
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