Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

@article{ElseguiArtola2016MechanicalRO,
  title={Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity},
  author={Alberto El{\'o}segui-Artola and Roger Oria and Yunfeng Chen and Anita Joanna Kosmalska and Carlos J. P{\'e}rez-Gonz{\'a}lez and Natalia de Castro and Cheng Zhu and Xavier Trepat and Pere Roca-Cusachs},
  journal={Nature Cell Biology},
  year={2016},
  volume={18},
  pages={540-548}
}
Cell function depends on tissue rigidity, which cells probe by applying and transmitting forces to their extracellular matrix, and then transducing them into biochemical signals. Here we show that in response to matrix rigidity and density, force transmission and transduction are explained by the mechanical properties of the actin–talin–integrin–fibronectin clutch. We demonstrate that force transmission is regulated by a dynamic clutch mechanism, which unveils its fundamental biphasic force… CONTINUE READING
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