Mechanical properties of fibroblasts depend on level of cancer transformation.

  title={Mechanical properties of fibroblasts depend on level of cancer transformation.},
  author={Yu.M. Efremov and Maria E Lomakina and D. V. Bagrov and P I Makhnovskiy and Antonina Y Alexandrova and M. P. Kirpichnikov and K. V. Shaitan},
  journal={Biochimica et biophysica acta},
  volume={1843 5},
Recently, it was revealed that tumor cells are significantly softer than normal cells. Although this phenomenon is well known, it is connected with many questions which are still unanswered. Among these questions are the molecular mechanisms which cause the change in stiffness and the correlation between cell mechanical properties and their metastatic potential. We studied mechanical properties of cells with different levels of cancer transformation. Transformed cells in three systems with… CONTINUE READING
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