Mechanical properties of brain tissue in-vivo: experiment and computer simulation.

@article{Miller2000MechanicalPO,
  title={Mechanical properties of brain tissue in-vivo: experiment and computer simulation.},
  author={Karol Miller and Kiyoyuki Chinzei and G J Orssengo and Piotr Bednarz},
  journal={Journal of biomechanics},
  year={2000},
  volume={33 11},
  pages={
          1369-76
        }
}

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References

SHOWING 1-10 OF 34 REFERENCES
Constitutive modelling of brain tissue: experiment and theory.
Constitutive model of brain tissue suitable for finite element analysis of surgical procedures.
  • K. Miller
  • Engineering
    Journal of biomechanics
  • 1999
A computational model for tracking subsurface tissue deformation during stereotactic neurosurgery
TLDR
The authors report on the initial development of a finite element model of brain tissue adapted from consolidation theory that could be used in conjunction with a limited amount of concurrently obtained operative data to estimate subsurface tissue motion.
Dynamic response of the human head to impact by three-dimensional finite element analysis.
TLDR
Interestingly, the model predicted higher contre-coup pressure in the frontal lobe (from occipital impact) than that predicted in the occipitals region from frontal impact, which supports clinical findings of contre -coup injury being more likely to result from occipITAL impact than from frontalimpact.
Calculation of brain elastic parameters in vivo.
TLDR
G0 is identified, a second-order pressure-depth ratio that characterizes the nonlinear behavior and, along with G0, can be evaluated from a mathematical relation that models the experimental results obtained from the elastic response test.
REGIONAL DIFFERENCES IN MECHANICAL PROPERTIES OF THE PORCINE CENTRAL NERVOUS SYSTEM
TLDR
These region-specific differences provide essential information for enhancing the understanding of traumatic brain injury mechanisms and should be incorporated into current anatomically detailed finite element models (FEM's).
Elastomechanical characterization of brain tissues.
A two-dimensional, finite element analysis of vasogenic brain edema.
TLDR
The results indicate that the FEM, applied to a model of vasogenic brain edema, can be used to predict the time course and regional distribution of fluid accumulation and the accompanying regional stress and deformation of brain tissue.
A constitutive relationship for large deformation finite element modeling of brain tissue.
TLDR
The use of a large strain constitutive relationship suitable for modeling brain tissue as well as other soft biological tissue is discussed, and the numerical results compare favorably with the experimental data.
Finite element analysis of cerebral contusion.
...
1
2
3
4
...