Mechanical phenotype of cancer cells: cell softening and loss of stiffness sensing

  title={Mechanical phenotype of cancer cells: cell softening and loss of stiffness sensing},
  author={Hong Cheu Lin and Hsiu-Kuan Lin and I-Hsuan Lin and Yu-Wei Chiou and Horn-Wei Chen and C Liu and Hans I-Chen Harn and Wen-Tai Chiu and Yang-Kao Wang and M R Shen and Ming-Jer Tang},
The stiffness sensing ability is required to respond to the stiffness of the matrix. Here we determined whether normal cells and cancer cells display distinct mechanical phenotypes. Cancer cells were softer than their normal counterparts, regardless of the type of cancer (breast, bladder, cervix, pancreas, or Ha-RasV12-transformed cells). When cultured on matrices of varying stiffness, low stiffness decreased proliferation in normal cells, while cancer cells and transformed cells lost this… CONTINUE READING


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Matrix Stiffness: A Regulator of Cellular Behavior and Tissue Formation

  • B Mason, J Califano, C. Reinhart-King
  • Engineering Biomaterials for Regenerative…
  • 2012
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