Mechanical loading regulates NOS expression and activity in developing and adult skeletal muscle.

@article{Tidball1998MechanicalLR,
  title={Mechanical loading regulates NOS expression and activity in developing and adult skeletal muscle.},
  author={James G. Tidball and Eliane Lavergne and Kim S. Lau and Melissa J Spencer and James T Stull and Michelle Wehling},
  journal={The American journal of physiology},
  year={1998},
  volume={275 1 Pt 1},
  pages={C260-6}
}
The hypothesis that changes in muscle activation and loading regulate the expression and activity of neuronal nitric oxide (NO) synthase (nNOS) was tested using in vitro and in vivo approaches. Removal of weight bearing from rat hindlimb muscles for 10 days resulted in a significant decrease in nNOS protein and mRNA concentration in soleus muscles, which returned to control concentrations after return to weight bearing. Similarly, the concentration of nNOS in cultured myotubes increased by… CONTINUE READING

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