Mechanical loading regulates NOS expression and activity in developing and adult skeletal muscle.

  title={Mechanical loading regulates NOS expression and activity in developing and adult skeletal muscle.},
  author={James G. Tidball and Eliane Lavergne and Kim S. Lau and Melissa J Spencer and James T Stull and Michelle Wehling},
  journal={The American journal of physiology},
  volume={275 1 Pt 1},
The hypothesis that changes in muscle activation and loading regulate the expression and activity of neuronal nitric oxide (NO) synthase (nNOS) was tested using in vitro and in vivo approaches. Removal of weight bearing from rat hindlimb muscles for 10 days resulted in a significant decrease in nNOS protein and mRNA concentration in soleus muscles, which returned to control concentrations after return to weight bearing. Similarly, the concentration of nNOS in cultured myotubes increased by… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 81 extracted citations

Nitric oxide regulates stretch-induced proliferation in C2C12 myoblasts

Journal of Muscle Research and Cell Motility • 2010
View 6 Excerpts
Highly Influenced

­­­Mechanosensitivity of aged muscle stem cells

Journal of orthopaedic research : official publication of the Orthopaedic Research Society • 2018
View 3 Excerpts
Highly Influenced

Adaptation of muscle size and myofascial force transmission: a review and some new experimental results.

Scandinavian journal of medicine & science in sports • 2005
View 3 Excerpts
Highly Influenced

Stretch-induced nitric oxide modulates mechanical properties of skeletal muscle cells.

American journal of physiology. Cell physiology • 2004
View 4 Excerpts
Highly Influenced

Acute exercise increases nitric oxide synthase activity in skeletal muscle.

American journal of physiology. Endocrinology and metabolism • 1999
View 6 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 36 references

"Nitric oxide release is present from incubated skeletal muscle preparations".

Journal of applied physiology • 1994
View 5 Excerpts
Highly Influenced

Neuronal nitric oxide synthase and dystrophin-deficient muscular dystrophy.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 1 Excerpt

268 ( Gastrointest

M. Sarih, V. Souvannavong, A. Adam
Liver Physiol . • 1995

Similar Papers

Loading similar papers…