Mechanical loading affects angiogenesis and osteogenesis in an in vivo bone chamber: a modeling study.

@article{Geris2010MechanicalLA,
  title={Mechanical loading affects angiogenesis and osteogenesis in an in vivo bone chamber: a modeling study.},
  author={Liesbet Geris and Katleen Vandamme and Ignace Naert and Jos Vander Sloten and Hans Van Oosterwyck and Joke Duyck},
  journal={Tissue engineering. Part A},
  year={2010},
  volume={16 11},
  pages={3353-61}
}
Despite a myriad of studies confirming the interaction between biology and mechanics, the exact nature of the main mechanical stimuli and their influence on the bone regeneration processes are still unclear. The hypothesis of this study was that the outcome of peri-implant healing under different implant loading regimens can be explained by the influence of fluid flow on the combination of angiogenesis and osteogenesis through its influence on cell proliferation and differentiation. To… CONTINUE READING