Mechanical load increases muscle IGF-I and androgen receptor mRNA concentrations in humans.

@article{Bamman2001MechanicalLI,
  title={Mechanical load increases muscle IGF-I and androgen receptor mRNA concentrations in humans.},
  author={Marcas M Bamman and J R Shipp and Jie Jiang and Barbara Gower and Gary Hunter and A D Goodman and Charles L McLafferty and Randall J. Urban},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2001},
  volume={280 3},
  pages={E383-90}
}
The mechanism(s) of load-induced muscle hypertrophy is as yet unclear, but increasing evidence suggests a role for locally expressed insulin-like growth factor I (IGF-I). We investigated the effects of concentric (CON) vs. eccentric (ECC) loading on muscle IGF-I mRNA concentration. We hypothesized a greater IGF-I response after ECC compared with CON. Ten healthy subjects (24.4 +/- 0.7 yr, 174.5 +/- 2.6 cm, 70.9 +/- 4.3 kg) completed eight sets of eight CON or ECC squats separated by 6-10 days… CONTINUE READING
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