Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection.

@article{Carams2012MechanicalIS,
  title={Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection.},
  author={Beatriz Caram{\'e}s and Noboru Taniguchi and Daisuke Seino and Francisco J Blanco and Darryl L D'Lima and Martin Lotz},
  journal={Arthritis and rheumatism},
  year={2012},
  volume={64 4},
  pages={1182-92}
}
OBJECTIVE Mechanical injury induces cell death in cartilage and triggers a remodeling process that ultimately can manifest as osteoarthritis. Autophagy is a process for turnover of intracellular organelles and macromolecules that protects cells during stress responses. This study was undertaken to determine changes in and functions of autophagy following… CONTINUE READING