Mechanical identities of RNA and DNA double helices unveiled at the single-molecule level.

@article{HerreroGaln2013MechanicalIO,
  title={Mechanical identities of RNA and DNA double helices unveiled at the single-molecule level.},
  author={El{\'i}as Herrero-Gal{\'a}n and Maria Eugenia Fuentes-Perez and Carolina Avila Carrasco and Jos{\'e} Mar{\'i}a Valpuesta and Jos{\'e} L Carrascosa and Fernando Moreno-Herrero and J. Ricardo Arias-Gonzalez},
  journal={Journal of the American Chemical Society},
  year={2013},
  volume={135 1},
  pages={122-31}
}
Double-stranded (ds) RNA is the genetic material of a variety of viruses and has been recently recognized as a relevant molecule in cells for its regulatory role. Despite that the elastic response of dsDNA has been thoroughly characterized in recent years in single-molecule stretching experiments, an equivalent study with dsRNA is still lacking. Here, we have engineered long dsRNA molecules for their individual characterization contrasting information with dsDNA molecules of the same sequence… CONTINUE READING

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