Mechanical hypernociception in experimental autoimmune encephalomyelitis.

  title={Mechanical hypernociception in experimental autoimmune encephalomyelitis.},
  author={David Rodrigues and Daniela Sachs and Ant{\^o}nio L{\'u}cio Teixeira},
  journal={Arquivos de neuro-psiquiatria},
  volume={67 1},
BACKGROUND Pain is an important clinical manifestation in multiple sclerosis (MS) patients, though it has been neglected in clinical and experimental researches. OBJECTIVE To investigate the nociceptive response in MOG35-55 experimental autoimmune encephalomyelitis (EAE)-induced mice. METHOD EAE was induced in 8 to 10 week old C57BL/6 female mice with an emulsion of MOG35-55, Complete Freund Adjuvant, Mycobacterium tuberculosis H37 RA and pertussis toxin. Nociception was evaluated by the… CONTINUE READING
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