Mechanical hyperalgesia in rat models of systemic and local hyperglycemia

@article{Dobretsov2003MechanicalHI,
  title={Mechanical hyperalgesia in rat models of systemic and local hyperglycemia},
  author={Maxim Dobretsov and Stephanie L. Hastings and Dmitry J Romanovsky and Joseph R. Stimers and Jun-Ming Zhang},
  journal={Brain Research},
  year={2003},
  volume={960},
  pages={174-183}
}
Mechanical hyperalgesia is an early symptom of diabetic neuropathy. To evaluate the mechanisms underlying this symptom, it was studied and compared in rat models of systemic and local hyperglycemia. Systemic hyperglycemia was induced by a single injection of streptozotocin (STZ, 50 mg/kg). Local hyperglycemia either in L(5) dorsal root ganglion (DRG) or a segment of the sciatic nerve at mid-thigh level was maintained by perfusion with 30-mM glucose solution delivered from a surgically implanted… CONTINUE READING
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