Mechanical distention modulates alveolar epithelial cell phenotypic expression by transcriptional regulation.

@article{Gutirrez1999MechanicalDM,
  title={Mechanical distention modulates alveolar epithelial cell phenotypic expression by transcriptional regulation.},
  author={Jorge Armando Guti{\'e}rrez and Robert D Ertsey and Louis M. Scavo and Erin Collins and Leland G. Dobbs},
  journal={American journal of respiratory cell and molecular biology},
  year={1999},
  volume={21 2},
  pages={223-9}
}
The development of a normal pulmonary alveolar epithelium, essential for gas exchange, is critical for the successful adaptation to extrauterine life. From observations of natural and experimental developmental abnormalities, it has been hypothesized that mechanical factors may play a role in regulating differentiation of the pulmonary alveolar epithelium. To test this hypothesis directly, we have investigated the in vitro effects of mechanical distention on the expression of specific markers… CONTINUE READING