Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs.

@article{Roberts2001MechanicalCI,
  title={Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs.},
  author={Susan R Roberts and Martin M. Knight and David A Lee and Dan L. Bader},
  journal={Journal of applied physiology},
  year={2001},
  volume={90 4},
  pages={
          1385-91
        }
}
Ca2+ signaling forms part of a possible mechanotransduction pathway by which chondrocytes may alter their metabolism in response to mechanical loading. In this study, a well-characterized model system utilizing bovine articular chondrocytes embedded in 4% agarose constructs was used to investigate the effect of physiological mechanical compressive strain applied after 1 and 3 days in culture. The intracellular Ca2+ concentration was measured by use of the ratiometric Ca2+ indicator indo 1-AM… CONTINUE READING

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