Mechanical compression alters proteoglycan deposition and matrix deformation around individual cells in cartilage explants.

@article{Quinn1998MechanicalCA,
  title={Mechanical compression alters proteoglycan deposition and matrix deformation around individual cells in cartilage explants.},
  author={T M Khayat Quinn and Alan J. Grodzinsky and Michael D. Buschmann and Yongjoo Kim and Ernst Bruno Hunziker},
  journal={Journal of cell science},
  year={1998},
  volume={111 ( Pt 5)},
  pages={573-83}
}
We have used new techniques of cell-length scale quantitative autoradiography to assess matrix synthesis, deposition, and deformation around individual chondrocytes in mechanically compressed cartilage explants. Our objectives were to: (1) quantify the effects of static and dynamic compression on the deposition of newly synthesized proteoglycans into cell-associated and further-removed matrices; (2) measure cell-length scale matrix strains and morphological changes of the cell and matrix… CONTINUE READING

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