Mechanical breath profile of airway pressure release ventilation: the effect on alveolar recruitment and microstrain in acute lung injury.

@article{KollischSingule2014MechanicalBP,
  title={Mechanical breath profile of airway pressure release ventilation: the effect on alveolar recruitment and microstrain in acute lung injury.},
  author={Michaela Kollisch-Singule and Bryanna M Emr and Bradford C. Smith and Shreyas Roy and Sumeet Jain and Joshua Satalin and Kathy P Snyder and Penny L Andrews and Nader M. Habashi and Jason H. T. Bates and William F. Marx and Gary F. Nieman and Louis Albert Gatto},
  journal={JAMA surgery},
  year={2014},
  volume={149 11},
  pages={
          1138-45
        }
}
IMPORTANCE Improper mechanical ventilation settings can exacerbate acute lung injury by causing a secondary ventilator-induced lung injury. It is therefore important to establish the mechanism by which the ventilator induces lung injury to develop protective ventilation strategies. It has been postulated that the mechanism of ventilator-induced lung injury is the result of heterogeneous, elevated strain on the pulmonary parenchyma. Acute lung injury has been associated with increases in whole… CONTINUE READING
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