Mechanical anisotropy of adherent cells probed by a three-dimensional magnetic twisting device.

@article{Hu2004MechanicalAO,
  title={Mechanical anisotropy of adherent cells probed by a three-dimensional magnetic twisting device.},
  author={Shaohua Hu and Luc Eberhard and Jianxin Chen and J. Christopher Love and James P. Butler and Jeffrey J. Fredberg and George M. Whitesides and Ning Wang},
  journal={American journal of physiology. Cell physiology},
  year={2004},
  volume={287 5},
  pages={
          C1184-91
        }
}
We describe a three-dimensional magnetic twisting device that is useful in characterizing the mechanical properties of cells. With the use of three pairs of orthogonally aligned coils, oscillatory mechanical torque was applied to magnetic beads about any chosen axis. Frequencies up to 1 kHz could be attained. Cell deformation was measured in response to torque applied via an RGD-coated, surface-bound magnetic bead. In both unpatterned and micropatterned elongated cells on extracellular matrix… CONTINUE READING

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