Mechanical and electrophysiological effects of 8-oxoberberine (JKL1073A) on atrial tissue.

  title={Mechanical and electrophysiological effects of 8-oxoberberine (JKL1073A) on atrial tissue.},
  author={J F Chi and Sang Hui Chu and Chull Sae Lee and Nai-Kuan Chou and M. Jai Su},
  journal={British journal of pharmacology},
  volume={118 3},
The effects of 8-oxoberberine (JKL1073A) on contractions and electrophysiological characteristics of atrial tissues were examined. In driven left atria of the rat JKL1073A (10-100 microM) increased twitch tension dose-dependently. In spontaneously beating right atria, JKL1073A increased twitch tension but decreased beating rate slightly. The positive inotropic and the negative chronotropic effect of 30 microM JKL1073A was not affected by prazosin (1 microM), propranolol (1 microM) and 3… CONTINUE READING

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