Mechanical and dimensional adaptation of rat aorta to hypertension.

  title={Mechanical and dimensional adaptation of rat aorta to hypertension.},
  author={Tetsuro Matsumoto and Kozaburo Hayashi},
  journal={Journal of biomechanical engineering},
  volume={116 3},
To investigate mechanisms of the mechanical adaptation of soft biological tissues to load, effects of hypertension on the mechanical properties and wall dimensions of thoracic aortas were studied in rats. Goldblatt hypertension was induced in male Wistar rats aged 8 to 9 weeks by constricting their left renal arteries. Two, 4, 8, or 16 weeks after the operation, thoracic aortas were excised and used to determine static pressure-diameter relations and wall dimensions. Wall thickness correlated… CONTINUE READING
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