Mechanical and architectural bone adaptation in early stage experimental osteoarthritis.

@article{Boyd2002MechanicalAA,
  title={Mechanical and architectural bone adaptation in early stage experimental osteoarthritis.},
  author={Steven K. Boyd and Ralph Mueller and Ronald F. Zernicke},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2002},
  volume={17 4},
  pages={
          687-94
        }
}
The purpose of this study was to quantify mechanical and architectural changes to knee joint periarticular subchondral cancellous bone in early stage experimental osteoarthritis (OA). Unilateral anterior cruciate ligament transection (ACLX) was performed on 10 dogs that were assigned randomly to two groups: 3 weeks or 12 weeks post-ACLX. Cylindrical bone cores excised from the medial condyle of the distal femur after death were scanned using high-resolution microcomputed tomography (muCT) and… CONTINUE READING

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