Mechanical and Metabolic Characterization of Ischemic Contracture in the Neonatal Pig Heart

@article{Ascuitto1995MechanicalAM,
  title={Mechanical and Metabolic Characterization of Ischemic Contracture in the Neonatal Pig Heart},
  author={Robert J. Ascuitto and Nancy T. Ross-Ascuitto and Donald W Kydon and Alice E. Waddell and Kathleen H Mcdonough},
  journal={Pediatric Research},
  year={1995},
  volume={38},
  pages={228-236}
}
ABSTRACT: Isolated, paced, isovolumetrically beating piglet hearts (n = 37) underwent retrograde aortic perfusion with a crystalloid solution during three periods: 1) baseline (coronary perfusion pressure 60 mm Hg), 2) ischemia (coronary flow 10% of baseline for ± 80 min), and 3) reperfusion (perfusion pressure returned to baseline). In one group of hearts, glycolysis (using 3H20 formation from [3H]glucose) was assessed. During baseline, peak systolic pressure (PSP) was 101.1 ± 5.0 mm Hg, end… CONTINUE READING

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