Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system.

@article{Otsubo2012MechanicalAB,
  title={Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system.},
  author={Yukiko Otsubo and Yasushi Satoh and Mitsuyoshi Kodama and Yoshiyuki Araki and Maiko Satomoto and Eiji Sakamoto and Gilles Pag{\'e}s and Jacques Pouyss{\'e}gur and Shogo Endo and Tomiei Kazama},
  journal={Pain},
  year={2012},
  volume={153 11},
  pages={2241-52}
}
Extracellular signal-regulated kinase (ERK) plays critical roles in pain plasticity. However, the specific contribution of ERK2 isoforms to pain plasticity is not necessarily elucidated. Here we investigate the function of ERK2 in mouse pain models. We used the Cre-loxP system to cause a conditional, region-specific, genetic deletion of Erk2. To induce recombination in the central nervous system, Erk2-floxed mice were crossed with nestin promoter-driven cre transgenic mice. In the spinal cord… CONTINUE READING
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