Mechanical actions of dendritic-spine enlargement on presynaptic exocytosis.

@article{Ucar2021MechanicalAO,
  title={Mechanical actions of dendritic-spine enlargement on presynaptic exocytosis.},
  author={Hasan Ucar and Satoshi Watanabe and Jun Noguchi and Yuichi Morimoto and Yusuke Iino and Sho Yagishita and Noriko Takahashi and Haruo Kasai},
  journal={Nature},
  year={2021}
}
Synaptic transmission involves cell-to-cell communication at the synaptic junction between two neurons, and chemical and electrical forms of this process have been extensively studied. In the brain, excitatory glutamatergic synapses are often made on dendritic spines that enlarge during learning1-5. As dendritic spines and the presynaptic terminals are tightly connected with the synaptic cleft6, the enlargement may have mechanical effects on presynaptic functions7. Here we show that fine and… 
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