Mechanical actions of dendritic-spine enlargement on presynaptic exocytosis.

  title={Mechanical actions of dendritic-spine enlargement on presynaptic exocytosis.},
  author={Hasan Ucar and Satoshi Watanabe and Jun Noguchi and Yuichi Morimoto and Yusuke Iino and Sho Yagishita and Noriko Takahashi and Haruo Kasai},
Synaptic transmission involves cell-to-cell communication at the synaptic junction between two neurons, and chemical and electrical forms of this process have been extensively studied. In the brain, excitatory glutamatergic synapses are often made on dendritic spines that enlarge during learning1-5. As dendritic spines and the presynaptic terminals are tightly connected with the synaptic cleft6, the enlargement may have mechanical effects on presynaptic functions7. Here we show that fine and… 
Membrane Stretch Gates NMDA Receptors
It is shown that, in addition to enhancing currents elicited with low agonist concentrations, membrane stretch can gate NMDARs in the absence of the neurotransmitter glutamate, which suggests that mechanical forces can initiate cellular processes presently attributed to glutamatergic neurotransmission, such as synaptic plasticity and cytotoxicity.
Disinhibition of Rab10 gates AMPAR insertion and spine enlargement during long-term potentiation
The results suggest that Rab10 and Rab4 oppositely regulate AMPAR trafficking during sLTP, and disinhibition of Rab10 signaling gates the induction of LTP and associated spine structural plasticity.
The thermodynamic soliton theory of the nervous impulse and possible medical implications.
  • T. Heimburg
  • Physics
    Progress in biophysics and molecular biology
  • 2022
A structural/methodological approach based on the occurrence of holes testifies once again how the simple biophysical structure alone can dictate the function.
Post-Synapses in the Brain: Role of Dendritic and Spine Structures
In the present review interest is focused on post-synapses, the structures receiving and converting pre-synaptic messages, which take place in neurodegenerative diseases and autism spectrum disorders.
Push the bouton
  • S. Lewis
  • Medicine
    Nature reviews. Neuroscience
  • 2021


The Spread of Ras Activity Triggered by Activation of a Single Dendritic Spine
Ca2+-dependent synaptic signals can spread to couple multiple synapses on short stretches of dendrite, and the spread of Ras-dependent signaling was necessary for the local regulation of the threshold for LTP induction.
Structural basis of long-term potentiation in single dendritic spines
The results indicate that spines individually follow Hebb's postulate for learning and suggest that small spines are preferential sites for long-term potentiation induction, whereas large spines might represent physical traces of long- term memory.
GABA promotes the competitive selection of dendritic spines by controlling local Ca2+ signaling
Two-color uncaging of glutamate and GABA in rat hippocampal CA1 pyramidal neurons is used and it is found that spine shrinkage and elimination were markedly promoted by the activation of GABAA receptors shortly before action potentials.
Protein Synthesis and Neurotrophin-Dependent Structural Plasticity of Single Dendritic Spines
In rat brain slices, the repetitive pairing of postsynaptic spikes and two-photon uncaging of glutamate at single spines (a spike-timing protocol) produced both immediate and gradual phases of spine enlargement in CA1 pyramidal neurons.
Distinct initial SNARE configurations underlying the diversity of exocytosis.
The manner in which the diversity of exocytosis reflects the initial configurations of SNARE assembly, including trans-SNARE, binary- SNARE, unitary-SNAR, and cis-SNare configurations, is summarized to clarify the common SNAREAssembly processes underlying exocyTosis and membrane trafficking in eukaryotic cells.
Synaptic cell adhesion.
The importance of synaptic cell adhesion molecules for brain function is highlighted by recent findings implicating several such molecules, notably neurexins and neuroligins, in schizophrenia and autism.
Ultrastructural evidence for synaptic scaling across the wake/sleep cycle
The hypothesis that a core function of sleep is to renormalize overall synaptic strength increased by wake is supported, as measured in mouse motor and sensory cortices.
Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy
The aim of this Review is to highlight some of the recent progress in elucidating the role of the actin cytoskeleton in synaptic function.