Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke Patients: A Meta-Analysis

@article{Mistry2017MechanicalTO,
  title={Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke Patients: A Meta-Analysis},
  author={Eva A. Mistry and Akshitkumar M. Mistry and Mohammad Obadah Nakawah and Rohan V. Chitale and Robert F. James and John Volpi and Matthew R. Fusco},
  journal={Stroke},
  year={2017},
  volume={48},
  pages={2450–2456}
}
Background and Purpose— Whether prior intravenous thrombolysis provides any additional benefits to the patients undergoing mechanical thrombectomy for large vessel, acute ischemic stroke remains unclear. Methods— We conducted a meta-analysis of 13 studies obtained through PubMed and EMBASE database searches to determine whether functional outcome (modified Rankin Scale) at 90 days, successful recanalization rate, and symptomatic intracerebral hemorrhage rate differed between patients who… 

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TLDR
IVT prior to MT is associated with increased excellent outcome and successful reperfusion rates, which support the use of bridging therapy.
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TLDR
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Intravenous Thrombolysis Before Mechanical Thrombectomy for Acute Ischemic Stroke: A Meta‐Analysis
TLDR
These findings support the use of dMT without intravenous thrombolysis bridging therapy, and find no significant differences in 90‐day functional outcome or mortality between dMT and BT, but a lower rate of symptomatic intracranial hemorrhage for dMT.
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TLDR
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TLDR
The pooled analysis indicates noninferiority of direct mechanical thrombectomy with a 4% margin of confidence, but the application of these findings is limited to patients presenting directly to mechanical thROMbectomy-capable centers and real-world workflow times may differ against those achieved in a trial setting.
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