Mechanical Stretching of Proteins: Calmodulin and Titin

Abstract

Mechanical unfolding of several domains of calmodulin and titin is studied using a Go-like model with a realistic contact map and Lennard-Jones contact interactions. It is shown that this simple model captures the experimentally observed difference between the two proteins: titin is a spring that is tough and strong whereas calmodulin acts like a weak… (More)
DOI: 10.1016/j.physa.2004.12.032

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