Mechanical Receptor–Related Mechanisms in Scar Management: A Review and Hypothesis

  title={Mechanical Receptor–Related Mechanisms in Scar Management: A Review and Hypothesis},
  author={Çağlayan Yağmur and Satoshi Akaishi and Rei Ogawa and Ethem Guneren},
  journal={Plastic and Reconstructive Surgery},
Background: The physiopathogenesis of proliferative scarring in human skin is not well understood. Furthermore, knowledge of the precise mechanisms of action for physical treatment modalities is limited. Compression garments, occlusive/adhesive skin taping, and silicone gel sheets are applied to form an occlusion on the scar surface, reduce tension, and/or increase pressure on the scar itself. The mechanisms by which the external or superficial actions of these treatments cause remission of a… 
Evidence-Based Scar Management: How to Improve Results with Technique and Technology
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Current concepts related to hypertrophic scarring in burn injuries
Exposure of the fat domes in the deep dermis is associated with increased HTS, possibly on the basis of altered interaction of adipose‐derived stem cells and the deep burn exudate.
Updated scar management practical guidelines: non-invasive and invasive measures.
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A composite device for scar control in burn injuries should involve a multimodal approach that incorporates strategies for control of contributing factors including the exposed nerve endings, stimulation of neuropeptide mediators, neurogenic inflammation, pruritis, mechanotension signaling and hydration.
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A composite device for scar control in burn injuries should involve a multimodal approach that incorporates strategies for control of contributing factors, including the exposed nerve endings, stimulation of neuropeptide mediators, neurogenic inflammation, pruritis and mechanotension signaling.


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This review explores the various treatment methods for hypertrophic scarring described in the literature including evidence-based therapies, standard practices, and emerging methods, attempting to distinguish those with clearly proven efficiency from anecdotal reports about therapies of doubtful benefits while trying to differentiate between prophylactic measures and actual treatment methods.
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The growing understanding of the molecular processes of normal and abnormal wound healing is promising for discovery of novel approaches for the management of hypertrophic scars and keloids.
Effects of mechanical compression on hypertrophic scars: prostaglandin E2 release.
[International clinical recommendations on scar management].
A qualitative overview of the available clinical literature by an international panel of experts using standard methods of appraisal highlights a primary role for silicon gel sheeting and intralesional corticosteroids in the management of a wide variety of abnormal scars.
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Making sense of hypertrophic scar: a role for nerves
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